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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Alper, Phil B; Deane, Jonathan; Betschart, Claudia; Buffet, David; Collignon Zipfel, Géraldine; Gordon, Perry; Hampton, Janice; Hawtin, Stuart; Ibanez, Maureen; Jiang, Tao; Junt, Tobias; Knoepfel, Thomas; Liu, Bo; Maginnis, Jillian; McKeever, Una; Michellys, Pierre-Yves; Mutnick, Daniel; Nayak, Bishnu; Niwa, Satoru; Richmond, Wendy; Rush, James S; Syka, Peter; Zhang, Yi; Zhu, Xuefeng.
Affiliation
  • Alper PB; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Deane J; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Betschart C; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Buffet D; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Collignon Zipfel G; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Gordon P; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Hampton J; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Hawtin S; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Ibanez M; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Jiang T; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Junt T; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Knoepfel T; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Liu B; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Maginnis J; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • McKeever U; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Michellys PY; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Mutnick D; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Nayak B; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Niwa S; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Richmond W; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Rush JS; Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes of Biomedical Research, 4002 Basel, Switzerland.
  • Syka P; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Zhang Y; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
  • Zhu X; Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.
Bioorg Med Chem Lett ; 30(17): 127366, 2020 09 01.
Article in En | MEDLINE | ID: mdl-32738975
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toll-Like Receptor 7 / Toll-Like Receptor 8 / Piperazine Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toll-Like Receptor 7 / Toll-Like Receptor 8 / Piperazine Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom