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High dose of baicalin or baicalein can reduce tight junction integrity by partly targeting the first PDZ domain of zonula occludens-1 (ZO-1).
Hisada, Misaki; Hiranuma, Minami; Nakashima, Mio; Goda, Natsuko; Tenno, Takeshi; Hiroaki, Hidekazu.
Affiliation
  • Hisada M; Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya, Aichi, 464-8601, Japan.
  • Hiranuma M; Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya, Aichi, 464-8601, Japan.
  • Nakashima M; Department of Biological Sciences, Faculty of Science, Nagoya University, Japan.
  • Goda N; Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya, Aichi, 464-8601, Japan.
  • Tenno T; Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya, Aichi, 464-8601, Japan; BeCerllBar, LLC., Nagoya, Aichi, Japan.
  • Hiroaki H; Graduate School of Pharmaceutical Sciences, Nagoya University, Furocho, Chikusa, Nagoya, Aichi, 464-8601, Japan; Department of Biological Sciences, Faculty of Science, Nagoya University, Japan; BeCerllBar, LLC., Nagoya, Aichi, Japan. Electronic address: hiroaki.hidekazu@f.mbox.nagoya-u.ac.jp.
Eur J Pharmacol ; 887: 173436, 2020 Nov 15.
Article in En | MEDLINE | ID: mdl-32745606
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Tight Junctions / Flavanones / PDZ Domains / Zonula Occludens-1 Protein Limits: Animals / Humans Language: En Journal: Eur J Pharmacol Year: 2020 Document type: Article Affiliation country: Japan Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Tight Junctions / Flavanones / PDZ Domains / Zonula Occludens-1 Protein Limits: Animals / Humans Language: En Journal: Eur J Pharmacol Year: 2020 Document type: Article Affiliation country: Japan Country of publication: Netherlands