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Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells.
Roudnicky, Filip; Zhang, Jitao David; Kim, Bo Kyoung; Pandya, Nikhil J; Lan, Yanjun; Sach-Peltason, Lisa; Ragelle, Heloise; Strassburger, Pamela; Gruener, Sabine; Lazendic, Mirjana; Uhles, Sabine; Revelant, Franco; Eidam, Oliv; Sturm, Gregor; Kueppers, Verena; Christensen, Klaus; Goldstein, Leonard D; Tzouros, Manuel; Banfai, Balazs; Modrusan, Zora; Graf, Martin; Patsch, Christoph; Burcin, Mark; Meyer, Claas A; Westenskow, Peter D; Cowan, Chad A.
Affiliation
  • Roudnicky F; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Zhang JD; Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; jitao_david.zhang@roche.com peter.westenskow@roche.com chadacowan@gmail.com.
  • Kim BK; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Pandya NJ; Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Lan Y; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Sach-Peltason L; Pharma Research and Early Development Informatics, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Ragelle H; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Strassburger P; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Gruener S; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Lazendic M; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Uhles S; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Revelant F; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Eidam O; Pharma Research and Early Development Informatics, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Sturm G; Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Kueppers V; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Christensen K; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Goldstein LD; Molecular Biology Department, Genentech Inc., South San Francisco, CA 94080.
  • Tzouros M; Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Banfai B; Pharmaceutical Sciences, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Modrusan Z; Molecular Biology Department, Genentech Inc., South San Francisco, CA 94080.
  • Graf M; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Patsch C; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Burcin M; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Meyer CA; Therapeutic Modalities, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland.
  • Westenskow PD; Ocular Technologies, Immunology, Infectious Diseases and Ophthalmology, Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; jitao_david.zhang@roche.com peter.westenskow@roche.com chadacowan@gmail.com.
  • Cowan CA; Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; jitao_david.zhang@roche.com peter.westenskow@roche.com chadacowan@gmail.com.
Proc Natl Acad Sci U S A ; 117(33): 19854-19865, 2020 08 18.
Article in En | MEDLINE | ID: mdl-32759214
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pluripotent Stem Cells / Endothelial Cells / Small Molecule Libraries Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pluripotent Stem Cells / Endothelial Cells / Small Molecule Libraries Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States