The effect of beta-blockers on a course of chronic heart failure in patients with a low triiodothyronine syndrome.
Wiad Lek
; 73(7): 1402-1409, 2020.
Article
in En
| MEDLINE
| ID: mdl-32759428
ABSTRACT
OBJECTIVE:
Theaim:
The aim is to study the effect of ß-ABs in patients with LT3 S on the course of HF. PATIENTS ANDMETHODS:
Materials andmethods:
354 patients with HF on a background of post-infarction cardiosclerosis were included in the 2-yeared follow-up study. LT3 S was diagnosed at 89 (25.1%) patients. The levels of thyroid-stimulating hormone, free T3f and T4f, and reversible T3 were determined. The echocardioscopy was performed.RESULTS:
Results:
Patients with HF in combination with LT3 S have a heavier functional class by NYHA, greater dilatation of the left heart cavities, less myocardial contractility, a higher frequency of atrial fibrillation and re-hospitalization. The use of ß-ABs in patients with HF without LT3 S leads to a likely decrease in hospitalization frequency, while in patients with LT3 S it has an opposite effect. The frequency of rehospitalization increases with an excess of ß-ABs dose > 5 mg (equivalent to bisoprolol). At these patients a decrease in serum T3 level and negative dynamics of parameters of intracardiac hemodynamics are observed.CONCLUSION:
Conclusions:
The use of ß-ABs in patients with LT3 S leads to an increase in re-hospitalization at a dose over 5.0 mg (equivalent to bisoprolol). In these patients there is a decrease in serum T3, an increase in T4 level; and the ejection fraction decrease; and heart cavities size increase.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Euthyroid Sick Syndromes
/
Heart Failure
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Wiad Lek
Journal subject:
MEDICINA
Year:
2020
Document type:
Article
Affiliation country:
Ukraine