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Evolution of SIVsm in humanized mice towards HIV-2.
Curlin, James; Schmitt, Kimberly; Remling-Mulder, Leila; Moriarty, Ryan; Goff, Kelly; O'Connor, Shelby; Stenglein, Mark; Marx, Preston; Akkina, Ramesh.
Affiliation
  • Curlin J; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Schmitt K; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Remling-Mulder L; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Moriarty R; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Goff K; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • O'Connor S; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Stenglein M; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
  • Marx P; Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Akkina R; Tulane National Primate Research Center, Covington, LA, USA.
J Med Primatol ; 49(5): 280-283, 2020 10.
Article in En | MEDLINE | ID: mdl-32777101
Through the accumulation of adaptive mutations, HIV-2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross-species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T-cell decline as the virus was passaged in humanized mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-2 / Simian Immunodeficiency Virus / CD4 Lymphocyte Count / Evolution, Molecular Limits: Animals Language: En Journal: J Med Primatol Year: 2020 Document type: Article Affiliation country: United States Country of publication: Denmark
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-2 / Simian Immunodeficiency Virus / CD4 Lymphocyte Count / Evolution, Molecular Limits: Animals Language: En Journal: J Med Primatol Year: 2020 Document type: Article Affiliation country: United States Country of publication: Denmark