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Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats.
Tokuno, Masahiro; Taguchi, Kazuaki; Sakai, Hiromi; Ohtsuki, Sumio; Yamasaki, Keishi; Otagiri, Masaki.
Affiliation
  • Tokuno M; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4-22-1, Nishi-Ku, Kumamoto, 860-0082, Japan.
  • Taguchi K; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4-22-1, Nishi-Ku, Kumamoto, 860-0082, Japan; Division of Pharmacodynamics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan. Electronic address: taguchi-kz@pha.keio.ac.
  • Sakai H; Department of Chemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
  • Ohtsuki S; Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
  • Yamasaki K; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4-22-1, Nishi-Ku, Kumamoto, 860-0082, Japan; DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-Ku, Kumamoto, 860-0082, Japan.
  • Otagiri M; Department of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4-22-1, Nishi-Ku, Kumamoto, 860-0082, Japan; DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-Ku, Kumamoto, 860-0082, Japan.
Drug Metab Pharmacokinet ; 35(5): 425-431, 2020 Oct.
Article in En | MEDLINE | ID: mdl-32788076
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tolbutamide / Midazolam / Caffeine / Hemoglobins / Chlorzoxazone / Cytochrome P-450 Enzyme System Limits: Animals Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tolbutamide / Midazolam / Caffeine / Hemoglobins / Chlorzoxazone / Cytochrome P-450 Enzyme System Limits: Animals Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United kingdom