Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.

Nelson, Luke T; Paxman, Ryan J; Xu, Jin; Webb, Bill; Powers, Evan T; Kelly, Jeffery W

Nelson, Luke T; Paxman, Ryan J; Xu, Jin; Webb, Bill; Powers, Evan T; Kelly, Jeffery W.

Affiliation

Nelson LT; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Paxman RJ; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Xu J; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Webb B; Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Powers ET; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

Amyloid ; 28(1): 24-29, 2021 Mar.

Article in En | MEDLINE | ID: mdl-32811187

Subject(s)

Amyloid Neuropathies, Familial/drug therapy; Amyloid/genetics; Cardiomyopathies/drug therapy; Prealbumin/genetics; Amyloid/antagonists & inhibitors; Amyloid/blood; Amyloid/chemistry; Amyloid Neuropathies, Familial/blood; Amyloid Neuropathies, Familial/genetics; Amyloid Neuropathies, Familial/pathology; Benzoates/pharmacology; Benzoxazoles/pharmacology; Cardiomyopathies/blood; Cardiomyopathies/genetics; Cardiomyopathies/pathology; Diflunisal/pharmacology; Humans; Kinetics; Prealbumin/chemistry; Protein Aggregates/drug effects; Protein Binding/drug effects; Protein Multimerization/drug effects; Protein Subunits/antagonists & inhibitors; Protein Subunits/blood; Protein Subunits/chemistry; Protein Subunits/genetics; Pyrazoles/pharmacology; Tolcapone/pharmacology

Key words

Kinetic stabilisation; Wild-type transthyretin (TTR) amyloid cardiomyopathy (ATTRwt-CM); amyloid angiopathy; hereditary transthyretin (TTR) amyloid cardiomyopathy (ATTRv-CM); leptomeningeal transthyretin (TTR) amyloidosis; senile systemic amyloidosis; transthyretin (TTR) central nervous system amyloidosis; transthyretin (TTR) eye amyloidosis; vitreous transthyretin (TTR) amyloidosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prealbumin / Amyloid Neuropathies, Familial / Amyloid / Cardiomyopathies Type of study: Prognostic_studies Limits: Humans Language: En Journal: Amyloid Journal subject: BIOQUIMICA Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

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