Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.
ChemMedChem
; 15(24): 2513-2520, 2020 12 15.
Article
in En
| MEDLINE
| ID: mdl-32812371
ABSTRACT
Combined photochemical arylation, "nuisance effect" (SN Ar) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein-ligand structure determination. Reactions were deliberately allowed to run "out of control" in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with SN Ar processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzene Derivatives
/
Enzyme Inhibitors
/
Small Molecule Libraries
Limits:
Humans
Language:
En
Journal:
ChemMedChem
Journal subject:
FARMACOLOGIA
/
QUIMICA
Year:
2020
Document type:
Article
Affiliation country:
United kingdom