Animal models of Chagas disease and their translational value to drug development.

Chatelain, Eric; Scandale, Ivan

Chatelain, Eric; Scandale, Ivan.

Affiliation

Chatelain E; R&D Department, Drugs for Neglected Diseases Initiative (DNDi) , Geneva, Switzerland.
Scandale I; R&D Department, Drugs for Neglected Diseases Initiative (DNDi) , Geneva, Switzerland.

Expert Opin Drug Discov ; 15(12): 1381-1402, 2020 12.

Article in En | MEDLINE | ID: mdl-32812830

Subject(s)

Chagas Disease/drug therapy; Drug Development; Trypanocidal Agents/administration & dosage; Animals; Chagas Disease/parasitology; Disease Models, Animal; Drug Discovery; Host-Parasite Interactions; Humans; Trypanocidal Agents/adverse effects; Trypanocidal Agents/pharmacology; Trypanosoma cruzi/isolation & purification

Key words

Trypanosoma cruzi; in vivo; Bioluminescence; imaging; parasitological cure; pharmacokinetic/pharmacodynamic relationships; predictability

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Chagas Disease / Drug Development Type of study: Prognostic_studies Aspects: Patient_preference Limits: Animals / Humans Language: En Journal: Expert Opin Drug Discov Year: 2020 Document type: Article Affiliation country: Switzerland

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google