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A sodium alginate-based nano-pesticide delivery system for enhanced in vitro photostability and insecticidal efficacy of phloxine B.
Yin, Yihua; Yang, Mengdan; Xi, Jing; Cai, Weiquan; Yi, Ying; He, Guanghua; Dai, Yue; Zhou, Ting; Jiang, Mengqing.
Affiliation
  • Yin Y; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China. Electronic address: yihuayin@aliyun.com.
  • Yang M; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
  • Xi J; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
  • Cai W; School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, PR China; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450002, PR China. Electronic address: cccaiwq@gzhu.edu.cn.
  • Yi Y; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
  • He G; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
  • Dai Y; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
  • Zhou T; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
  • Jiang M; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, PR China.
Carbohydr Polym ; 247: 116677, 2020 Nov 01.
Article in En | MEDLINE | ID: mdl-32829805
To improve in vitro photostability and enhance insecticidal activity, a novel esterase/glutathione (GSH) responsive photoactivated nano-pesticide delivery system was synthesized by conjugation of photoactivated pesticide phloxine B(PB) to sodium alginate (SA) via esterase/GSH sensitive phenolic ester bond followed by ultrasonic dispersion. The system was stable in PBS (pH 7.4) and could protect effectively the conjugated PB from in vitro photodegradation because of aggregation-caused quenching effect, whose maximum photodegradation rate did not exceed 10 % after 270 min illumination. However, upon exposure to esterase-6 or GSH stimulus, high photoactivity was observed due to the destruction of the system and accompanied by PB release. The combined stimulation could trigger more PB release than any single stimulus and thus resulting in a higher photoactivity. Compared with free PB, The system showed a higher phototoxicity on Sf9 insect cells and the in vitro light exposure had little influence on the phototoxicity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Eosine I Bluish / Alginates / Nanoconjugates Limits: Animals Language: En Journal: Carbohydr Polym Year: 2020 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Eosine I Bluish / Alginates / Nanoconjugates Limits: Animals Language: En Journal: Carbohydr Polym Year: 2020 Document type: Article Country of publication: United kingdom