Clinical and Demographic Characteristics of Upper Limb Dystonia.
Mov Disord
; 35(11): 2086-2090, 2020 11.
Article
in En
| MEDLINE
| ID: mdl-32845549
ABSTRACT
BACKGROUND:
Knowledge of characteristics in upper limb dystonia remains limited, derived primarily from small, single-site studies.OBJECTIVE:
The objective of this study was to characterize demographic and clinical characteristics of upper limb dystonia from the Dystonia Coalition data set, a large, international, multicenter resource.METHODS:
We evaluated clinical and demographic characteristics of 367 participants with upper limb dystonia from onset, comparing across subcategories of focal (with and without dystonia spread) versus nonfocal onset.RESULTS:
Focal onset occurred in 80%; 67% remained focal without spread. Task specificity was most frequent in this subgroup, most often writer's cramp and affecting the dominant limb (83%). Focal onset with spread was more frequent in young onset (<21 years). Focal onset occurred equally in women and men; nonfocal onset affected women disproportionately.CONCLUSIONS:
Upper limb dystonia distribution, focality, and task specificity relate to onset age and likelihood of regional spread. Observations may inform clinical counseling and design, execution, and interpretation of future studies. © 2020 International Parkinson and Movement Disorder Society.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dystonic Disorders
/
Dystonia
Type of study:
Clinical_trials
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Mov Disord
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
United States