Clinical efficacy of combination therapy of itraconazole and prednisolone for treating effusive feline infectious peritonitis.
J Vet Med Sci
; 82(10): 1492-1496, 2020 Oct 20.
Article
in En
| MEDLINE
| ID: mdl-32848107
ABSTRACT
A 3-month-old male Scottish Fold kitten with pleural fluid and low ratio of albumin to globulin (A/G ratio) was brought to our small animal hospital. Since RNA from the type I feline coronavirus (FCoV) were detected in drained pleural fluid, the cat was tentatively diagnosed with effusive feline infectious peritonitis (FIP). Following the administration of itraconazole and prednisolone, the A/G ratio increased, and the pleural fluid mostly disappeared. The fecal FCoV levels temporarily decreased. However, the cat showed neurological manifestations and was eventually euthanized due to status epilepticus after 38 days of treatment. In conclusion, itraconazole partly exerted a beneficial effect in a cat with FIP. However, further investigation of a possible role of itraconazole in FIP treatment is warranted.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prednisolone
/
Feline Infectious Peritonitis
/
Itraconazole
/
14-alpha Demethylase Inhibitors
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
J Vet Med Sci
Journal subject:
MEDICINA VETERINARIA
Year:
2020
Document type:
Article
Affiliation country:
Japan