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Coupled immune stratification and identification of therapeutic candidates in patients with lung adenocarcinoma.
Hu, Weilei; Wang, Guosheng; Chen, Yundi; Yarmus, Lonny B; Liu, Biao; Wan, Yuan.
Affiliation
  • Hu W; Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China.
  • Wang G; Center for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
  • Chen Y; The Pq Laboratory of Micro/Nano BiomeDx, Department of Biomedical Engineering, Binghamton University-SUNY, Binghamton, NY 13902, United States.
  • Yarmus LB; The Pq Laboratory of Micro/Nano BiomeDx, Department of Biomedical Engineering, Binghamton University-SUNY, Binghamton, NY 13902, United States.
  • Liu B; Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21218, United States.
  • Wan Y; Department of Pathology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215006, Jiangsu, China.
Aging (Albany NY) ; 12(16): 16514-16538, 2020 08 27.
Article in En | MEDLINE | ID: mdl-32855362
In recent years, personalized cancer immunotherapy, especially stratification-driven precision treatments have gained significant traction. However, due to the heterogeneity in clinical cohorts, the uncombined analysis of stratification/therapeutics may lead to confusion in determining ideal therapeutic options. We report that the coupled immune stratification and drug repurposing could facilitate identification of therapeutic candidates in patients with lung adenocarcinoma (LUAD). First, we categorized the patients into four groups based on immune gene profiling, associated with distinct molecular characteristics and clinical outcomes. Then, the weighted gene co-expression network analysis (WGCNA) algorithm was used to identify co-expression modules of each groups. We focused on C3 group which is characterized by low immune infiltration (cold tumor) and wild-type EGFR, posing a significant challenge for treatment of LUAD. Five drug candidates against the C3 status were identified which have potential dual functions to correct aberrant immune microenvironment and also halt tumorigenesis. Furthermore, their steady binding affinity against the targets was verified through molecular docking analysis. In sum, our findings suggest that such coupled analysis could be a promising methodology for identification and exploration of therapeutic candidates in the practice of personalized immunotherapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Drug Repositioning / Transcriptome / Adenocarcinoma of Lung / Lung Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Document type: Article Affiliation country: China Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Drug Repositioning / Transcriptome / Adenocarcinoma of Lung / Lung Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2020 Document type: Article Affiliation country: China Country of publication: United States