Clinical features and potential risk factors for discerning the critical cases and predicting the outcome of patients with COVID-19.
J Clin Lab Anal
; 34(10): e23547, 2020 Oct.
Article
in En
| MEDLINE
| ID: mdl-32860454
ABSTRACT
OBJECTIVE:
To investigate the clinical features and risk factors for discerning the critical and predicting the outcome of patients with COVID-19.METHODS:
Patients who were admitted to the intensive care unit (ICU) department and general infection department of TaiKang Tongji (Wuhan) Hospital from February 10 to March 27, 2020, were included. Data on clinical features, complications, laboratory parameters, chest CT, nutrient requirement, and electrolyte imbalance were analyzed retrospectively.RESULTS:
A total of 123 (50 critical and 73 non-critical) patients were enrolled. 65% of patients with comorbidities, hypertension (45.5%), diabetes (21.9%), 36.5% of patients had more than one comorbidity. The proportion of lymphocytes in critical patients was significantly lower than that of non-critical patients. The proportion of patients with increased NLR, PLR, IL-6, CRP levels, and chest CT score was significantly higher in the critical than that of non-critical patients. The logistic regression analysis identified low lymphocyte count, high NLR, PLR, IL-6, CRP levels, and CT score as independent factors for discerning critical cases and high NLR, PLR, IL-6, and CT score could predict poor clinical outcome. Furthermore, we identified patients who needed nutrition support (HR 16.99) and with correction of electrolyte imbalance (HR 18.24) via intravenous injection were more likely to have a poor outcome.CONCLUSIONS:
The potential risk factors of lower lymphocyte count, high levels of NLR, PLR, IL-6, CRP, chest CT score, and the statue of nutrient requirement or electrolyte imbalance could assist clinicians in discerning critical cases and predict the poor outcome in patients with COVID-19.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Pandemics
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Clin Lab Anal
Journal subject:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2020
Document type:
Article
Affiliation country:
China