Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.

Niu, Yanfen; Yang, Pingfen; Li, Hongjian; Li, Qiang; Lin, Hua; Gao, Lihui; Li, Ling

Niu, Yanfen; Yang, Pingfen; Li, Hongjian; Li, Qiang; Lin, Hua; Gao, Lihui; Li, Ling.

Affiliation

Niu Y; Biomedical Engineering Research Center, Kunming Medical University.
Yang P; Biomedical Engineering Research Center, Kunming Medical University.
Li H; Department of Computer Science and Engineering, Chinese University of Hong Kong.
Li Q; School of Biomedical Sciences, Chinese University of Hong Kong.
Lin H; Biomedical Engineering Research Center, Kunming Medical University.
Gao L; Biomedical Engineering Research Center, Kunming Medical University.
Li L; Biomedical Engineering Research Center, Kunming Medical University.

Biol Pharm Bull ; 43(11): 1653-1659, 2020 Nov 01.

Article in En | MEDLINE | ID: mdl-32863294

Subject(s)

Aminosalicylic Acids/pharmacology; Hyperuricemia/drug therapy; Organic Anion Transporters, Sodium-Independent/agonists; Renal Elimination/drug effects; Uric Acid/metabolism; Aminosalicylic Acids/therapeutic use; Animals; Blood Urea Nitrogen; Creatinine/blood; Creatinine/urine; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Transport Proteins, Facilitative/antagonists & inhibitors; Glucose Transport Proteins, Facilitative/metabolism; Humans; Hyperuricemia/blood; Hyperuricemia/physiopathology; Hyperuricemia/urine; Kidney Tubules, Proximal/drug effects; Kidney Tubules, Proximal/metabolism; Kidney Tubules, Proximal/physiopathology; Male; Mice; Monosaccharide Transport Proteins/antagonists & inhibitors; Monosaccharide Transport Proteins/metabolism; Organic Anion Transport Protein 1/agonists; Organic Anion Transport Protein 1/metabolism; Organic Anion Transporters, Sodium-Independent/metabolism; Rats; Rats, Sprague-Dawley; Renal Elimination/physiology; Renal Reabsorption/drug effects; Renal Reabsorption/physiology; Sodium-Phosphate Cotransporter Proteins, Type I/agonists; Sodium-Phosphate Cotransporter Proteins, Type I/metabolism; Uric Acid/blood; Uric Acid/urine

Key words

hyperuricemia; olsalazine sodium; urate excretion; urate transporter

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Organic Anion Transporters, Sodium-Independent / Hyperuricemia / Renal Elimination / Aminosalicylic Acids Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2020 Document type: Article Country of publication: Japan

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