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Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein-Mediated Drug-Drug Interactions in Healthy Volunteers.
Miyake, Takeshi; Kimoto, Emi; Luo, Lina; Mathialagan, Sumathy; Horlbogen, Lauren M; Ramanathan, Ragu; Wood, Linda S; Johnson, Jillian G; Le, Vu H; Vourvahis, Manoli; Rodrigues, A David; Muto, Chieko; Furihata, Kenichi; Sugiyama, Yuichi; Kusuhara, Hiroyuki.
Affiliation
  • Miyake T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
  • Kimoto E; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Luo L; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Mathialagan S; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Horlbogen LM; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Ramanathan R; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Wood LS; Clinical Pharmacogenomics Laboratory, Early Clinical Development, Pfizer Inc, Groton, Connecticut, USA.
  • Johnson JG; Clinical Pharmacogenomics Laboratory, Early Clinical Development, Pfizer Inc, Groton, Connecticut, USA.
  • Le VH; Biostatics, Pfizer Inc., Collegeville, Pennsylvania, USA.
  • Vourvahis M; Clinical Pharmacology, Pfizer Inc., New York, New York, USA.
  • Rodrigues AD; ADME Sciences, Medicine Design, Pfizer Inc., Groton, Connecticut, USA.
  • Muto C; Clinical Pharmacology, Pfizer R&D Japan, Tokyo, Japan.
  • Furihata K; P-One Clinic, Keikokai Medical Corp, Tokyo, Japan.
  • Sugiyama Y; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan.
  • Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Clin Pharmacol Ther ; 109(2): 507-516, 2021 02.
Article in En | MEDLINE | ID: mdl-32866300
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Organic Cation Transport Proteins / Drug Interactions Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacol Ther Year: 2021 Document type: Article Affiliation country: Japan Country of publication: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Organic Cation Transport Proteins / Drug Interactions Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacol Ther Year: 2021 Document type: Article Affiliation country: Japan Country of publication: United States