Anti-Fibrotic Effect of Human Wharton's Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1.

Choi, Alee; Park, Sang Eon; Jeong, Jang Bin; Choi, Suk-Joo; Oh, Soo-Young; Ryu, Gyu Ha; Lee, Jeehun; Jeon, Hong Bae; Chang, Jong Wook

Choi, Alee; Park, Sang Eon; Jeong, Jang Bin; Choi, Suk-Joo; Oh, Soo-Young; Ryu, Gyu Ha; Lee, Jeehun; Jeon, Hong Bae; Chang, Jong Wook.

Affiliation

Choi A; Stem Cell Institute, ENCell Co. Ltd., Seoul 06072, Korea.
Park SE; Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Seoul 06351, Korea.
Jeong JB; Stem Cell Institute, ENCell Co. Ltd., Seoul 06072, Korea.
Choi SJ; Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Seoul 06351, Korea.
Oh SY; Stem Cell Institute, ENCell Co. Ltd., Seoul 06072, Korea.
Ryu GH; Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Seoul 06351, Korea.
Lee J; Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul 06351, Korea.
Jeon HB; Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul 06351, Korea.
Chang JW; Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Int J Mol Sci ; 21(17)2020 Aug 29.

Article in En | MEDLINE | ID: mdl-32872523

Subject(s)

Matrix Metalloproteinase 13/metabolism; Mesenchymal Stem Cells/metabolism; Muscle, Skeletal/cytology; Muscular Dystrophy, Duchenne/therapy; Administration, Intravenous; Animals; Cell Line; Dipeptides/pharmacology; Extracellular Matrix/metabolism; Female; Hydrogen Peroxide/adverse effects; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred mdx; Muscle Cells/drug effects; Muscle Cells/metabolism; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Muscular Dystrophy, Duchenne/metabolism; Muscular Dystrophy, Duchenne/pathology; Pregnancy; Tissue Inhibitor of Metalloproteinase-1/pharmacology; Treatment Outcome

Key words

Duchenne muscular dystrophy; Wharton's jelly-derived mesenchymal stem cell; matrix metalloproteinase-1; paracrine factor; skeletal muscle fibrosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Muscular Dystrophy, Duchenne / Matrix Metalloproteinase 13 / Mesenchymal Stem Cells Type of study: Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Country of publication: Switzerland

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