Dietary diversity is associated with longitudinal changes in hippocampal volume among Japanese community dwellers.
Eur J Clin Nutr
; 75(6): 946-953, 2021 06.
Article
in En
| MEDLINE
| ID: mdl-32879451
ABSTRACT
BACKGROUND/OBJECTIVES:
Dietary habits are known to affect health, including the rate of brain ageing and susceptibility to diseases. This study examines the longitudinal relationship between dietary diversity and hippocampal volume, which is a key structure of memory processing and is known to be impaired in dementia. SUBJECTS/METHODS:
Subjects were aged 40-89 years (n = 1683, men 50.6%) and participated in a 2-year follow-up study of the National Institute for Longevity Sciences-Longitudinal Study of Aging. Dietary intake was calculated from 3-day dietary records, and dietary diversity was determined using the Quantitative Index for Dietary Diversity at baseline. Longitudinal changes in hippocampal and total grey matter volumes were estimated by T1-weighted brain magnetic resonance imaging and FreeSurfer software. Estimated mean brain volume change in relation to dietary diversity score quintiles was assessed by the general linear model, adjusted for age, sex, education, smoking status, alcohol intake, physical activity, and comorbidities.RESULTS:
The mean (± standard deviation) % decreases in hippocampal and total grey matter volume during the 2-year follow-up were 1.00% (±2.27%) and 0.78% (±1.83%), respectively. Multivariate-adjusted decreases in total grey matter volume were associated with dietary diversity score (p = 0.065, p for trend = 0.017), and the % decrease in hippocampal volume was more strongly associated with the dietary diversity score the estimated mean (± standard error) values were 1.31% (±0.12%), 1.07% (±0.12%), 0.98% (±0.12%), 0.81% (±0.12%), and 0.85% (±0.12%), according to dietary diversity quintiles in ascending order (p = 0.030, p for trend = 0.003).CONCLUSIONS:
Among community dwellers, increased dietary diversity may be a new nutritional strategy to prevent hippocampal atrophy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diet
/
Hippocampus
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Eur J Clin Nutr
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2021
Document type:
Article
Affiliation country:
Japan