Effect of Anti-Glutamate Antibodies in Modeled Parkinsonian Syndrome.
Bull Exp Biol Med
; 169(4): 431-434, 2020 Aug.
Article
in En
| MEDLINE
| ID: mdl-32889565
ABSTRACT
We studied the effect of single and repeated intranasal administration of antibodies to glutamate in experimental parkinsonian syndrome induced by injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to C57BL/6J mice. Intranasal administration of anti-glutamate antibodies to mice in parallel with administration of MPTP over 10 days alleviated parkinsonian symptoms (oligokinesia and rigidity). In the serum of mice injected with antibodies to glutamate and/or MPTP, the titers of autoantibodies to glutamate and dopamine were higher than in control animals receiving saline. Single intranasal administration of anti-glutamate antibodies to mice with established parkinsonian syndrome did not affect the severity of parkinsonian symptoms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dopamine
/
Hypokinesia
/
Glutamic Acid
/
Parkinsonian Disorders
/
Antibodies
/
Antiparkinson Agents
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2020
Document type:
Article
Affiliation country:
RUSSIA