Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity.
Curr Top Med Chem
; 21(5): 377-403, 2021.
Article
in En
| MEDLINE
| ID: mdl-32901583
ABSTRACT
Indole, a heterocyclic organic compound, is one of the most promising heterocycles found in natural and synthetic sources since its derivatives possess fascinating structural diversity and various therapeutic properties. Indole alkaloids, synthetic dimers and hybrids could act on diverse targets in cancer cells, and consequently, possess potential antiproliferative effects on various cancers both in vitro and in vivo. Vinblastine, midostaurin, and anlotinib as the representative of indole alkaloids, synthetic dimers and hybrids respectively, have already been clinically applied to treat many types of cancers, demonstrating indole alkaloids, synthetic dimers and hybrids are useful scaffolds for the development of novel anticancer agents. Covering articles published between 2010 and 2020, this review emphasizes the recent development of indole alkaloids, synthetic dimers and hybrids with potential in vivo therapeutic application for cancers.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Indole Alkaloids
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Curr Top Med Chem
Journal subject:
QUIMICA
Year:
2021
Document type:
Article
Affiliation country:
China