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Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells.
Gudkova, O I; Demchenko, A G; Shvets, A V; Kuryakov, V N; Sedyakina, N E; Lyundup, A V; Feldman, N B; Gromovykh, T I; Lutsenko, S V.
Affiliation
  • Gudkova OI; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Demchenko AG; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Shvets AV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Kuryakov VN; Oil and Gas Research Institute, Russian Academy of Sciences, Moscow, Russia.
  • Sedyakina NE; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Lyundup AV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Feldman NB; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. n_feldman@mail.ru.
  • Gromovykh TI; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
  • Lutsenko SV; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med ; 169(4): 508-511, 2020 Aug.
Article in En | MEDLINE | ID: mdl-32910380
A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration - suppressed metabolic activity and viability of hepatoma cells. The EC50 for the stimulating effect was 32.8 µg/ml, and the IC50=602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tricarboxylic Acids / Alkanes / Nanoparticles / Coriolaceae / Antineoplastic Agents Limits: Humans Language: En Journal: Bull Exp Biol Med Year: 2020 Document type: Article Affiliation country: Russia Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tricarboxylic Acids / Alkanes / Nanoparticles / Coriolaceae / Antineoplastic Agents Limits: Humans Language: En Journal: Bull Exp Biol Med Year: 2020 Document type: Article Affiliation country: Russia Country of publication: United States