Synthesis and activity of novel indirubin derivatives.

Sun, Bin; Wang, Jiahao; Liu, Luohua; Mao, Longfei; Peng, Lizeng; Wang, Yuwei

Sun, Bin; Wang, Jiahao; Liu, Luohua; Mao, Longfei; Peng, Lizeng; Wang, Yuwei.

Affiliation

Sun B; College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, China.
Wang J; Jinan Asia Pharma Tech Company LTD., Jinan, China.
Liu L; State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, China.
Mao L; Jinan Asia Pharma Tech Company LTD., Jinan, China.
Peng L; Jinan Asia Pharma Tech Company LTD., Jinan, China.
Wang Y; College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an/Xianyang, China.

Chem Biol Drug Des ; 97(3): 565-571, 2021 03.

Article in En | MEDLINE | ID: mdl-32914538

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/metabolism; Antineoplastic Agents/pharmacology; Binding Sites; Cell Line, Tumor; Cell Proliferation/drug effects; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism; Indoles/chemistry; Indoles/metabolism; Indoles/pharmacology; Molecular Docking Simulation; Structure-Activity Relationship

Key words

IDO1 enzyme inhibitory activity; anti-proliferative activities; indirubin derivatives; synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Agents Limits: Humans Language: En Journal: Chem Biol Drug Des Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2021 Document type: Article Affiliation country: China Country of publication: United kingdom

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