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Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models.
Afflerbach, Ann-Kristin; Kiri, Mark D; Detinis, Tahir; Maoz, Ben M.
Affiliation
  • Afflerbach AK; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Kiri MD; Faculty of Biosciences, Universität Heidelberg, 69120 Heidelberg, Germany.
  • Detinis T; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Maoz BM; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
Biomolecules ; 10(9)2020 09 10.
Article in En | MEDLINE | ID: mdl-32927777
ABSTRACT
The human-relevance of an in vitro model is dependent on two main factors-(i) an appropriate human cell source and (ii) a modeling platform that recapitulates human in vivo conditions. Recent years have brought substantial advancements in both these aspects. In particular, mesenchymal stem cells (MSCs) have emerged as a promising cell source, as these cells can differentiate into multiple cell types, yet do not raise the ethical and practical concerns associated with other types of stem cells. In turn, advanced bioengineered in vitro models such as microfluidics, Organs-on-a-Chip, scaffolds, bioprinting and organoids are bringing researchers ever closer to mimicking complex in vivo environments, thereby overcoming some of the limitations of traditional 2D cell cultures. This review covers each of these advancements separately and discusses how the integration of MSCs into novel in vitro platforms may contribute enormously to clinical and fundamental research.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoids / Cell Lineage / Tissue Engineering / Mesenchymal Stem Cells / Cell- and Tissue-Based Therapy / Models, Biological Type of study: Prognostic_studies Aspects: Ethics Limits: Humans Language: En Journal: Biomolecules Year: 2020 Document type: Article Affiliation country: Israel

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organoids / Cell Lineage / Tissue Engineering / Mesenchymal Stem Cells / Cell- and Tissue-Based Therapy / Models, Biological Type of study: Prognostic_studies Aspects: Ethics Limits: Humans Language: En Journal: Biomolecules Year: 2020 Document type: Article Affiliation country: Israel