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Afterhyperpolarization amplitude in CA1 pyramidal cells of aged Long-Evans rats characterized for individual differences.
Severin, Daniel; Gallagher, Michela; Kirkwood, Alfredo.
Affiliation
  • Severin D; Department of Neurosciences, Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Gallagher M; Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA.
  • Kirkwood A; Department of Neurosciences, Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA. Electronic address: kirkwood@jhu.edu.
Neurobiol Aging ; 96: 43-48, 2020 12.
Article in En | MEDLINE | ID: mdl-32932137
Altered neural excitability is considered a prominent contributing factor to cognitive decline during aging. A clear example is the excess neural activity observed in several temporal lobe structures of cognitively impaired older individuals in rodents and humans. At a cellular level, aging-related changes in mechanisms regulating intrinsic excitability have been well examined in pyramidal cells of the CA1 hippocampal subfield. Studies in the inbred Fisher 344 rat strain document an age-related increase in the slow afterhyperpolarization (AHP) that normally occurs after a burst of action potentials, and serves to reduce subsequent firing. We evaluated the status of the AHP in the outbred Long-Evans rat, a well-established model for studying individual differences in neurocognitive aging. In contrast to the findings reported in the Fisher 344 rats, in the Long-Evan rats we detected a selective reduction in AHP in cognitively impaired aged individuals. We discuss plausible scenarios to account for these differences and also discuss possible implications of these differences.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyramidal Cells / Patch-Clamp Techniques / CA1 Region, Hippocampal / Cognitive Aging Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurobiol Aging Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyramidal Cells / Patch-Clamp Techniques / CA1 Region, Hippocampal / Cognitive Aging Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurobiol Aging Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States