Distinct T-cell immunophenotypic signature in a subset of sarcoidosis patients with arthritis.
J R Coll Physicians Edinb
; 50(3): 226-232, 2020 Sep.
Article
in En
| MEDLINE
| ID: mdl-32936094
ABSTRACT
BACKGROUND:
The objective of the study was to assess T-cell subsets in sarcoidosis patients with or without articular involvement.METHODS:
Treatment-naïve patients were divided into Group A (articular) and Group B (non-articular) based on joint involvement. Flow cytometric analysis of T-cell subsets and pro-inËflammatory cytokines were carried out in the peripheral blood.RESULTS:
Patients in group A (n = 29, mean age 40 ± 10.1 years) were compared with group B (n = 18, 43 ± 12.2 years). T-cell subsets the CD4/CD8 ratio was abnormal in two groups but had no significant difference (p = 0.63). Ratios of Th1/Treg, Th2/Treg and Th17/Treg were significantly increased in group A as compared to group B [p < 0.001] indicating polarisation of T-cell subsets. CD8 T-cells in group A had higher granzyme B expression (p = 0.03). B cells were increased in group A [p = 0.04]. Ratio of IFN-γ /IL10, IL-4/IL10, IL-17/IL10 in sera as well as culture supernatant were significantly higher in group A as compared to group B.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis
/
Sarcoidosis
Limits:
Adult
/
Humans
Language:
En
Journal:
J R Coll Physicians Edinb
Journal subject:
EDUCACAO
/
HISTORIA DA MEDICINA
/
MEDICINA
Year:
2020
Document type:
Article
Affiliation country:
India