A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling.
Org Lett
; 22(19): 7433-7438, 2020 Oct 02.
Article
in En
| MEDLINE
| ID: mdl-32941045
ABSTRACT
An operationally simple mechanochemical C-S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2020
Document type:
Article
Affiliation country:
United kingdom