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Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial.
Noh, Tae-Soo; Kyong, Jeong-Sug; Park, Moo Kyun; Lee, Jun Ho; Oh, Seung Ha; Suh, Myung-Whan.
Affiliation
  • Noh TS; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of medicine, Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea.
  • Kyong JS; Department of Audiology and Speech-Language Pathology, Audiology Institute, Hallym University of Graduate Studies, Seoul, Korea.
  • Park MK; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of medicine, Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea.
  • Lee JH; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of medicine, Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea.
  • Oh SH; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of medicine, Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea.
  • Suh MW; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of medicine, Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea. drmung@naver.com.
Brain Topogr ; 33(6): 767-775, 2020 11.
Article in En | MEDLINE | ID: mdl-32944806
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an alternative option for treating tinnitus. rTMS is a noninvasive method in which repetitive magnetic stimulation is applied to the cortex; it is considered a therapeutic strategy that modulates the loudness of tinnitus. In this study, we performed a double-blind randomized clinical trial to compare the outcome of tinnitus treatment among (1) dual-site (auditory + prefrontal) rTMS stimulation, (2) auditory cortex only rTMS stimulation (AC), and (3) sham stimulation. The left primary auditory cortex and left dorsolateral prefrontal cortex (DLPFC) were targeted independently of handedness or tinnitus laterality. Dual-site and auditory only groups were treated with a total of 12,000 pulses, 2000 pulses over the AC and 1000 pulses over the DLPFC (group 1), 3000 pulses over the AC only (group 2), and daily for 4 consecutive days. Dual-site group exhibited a significantly better ΔTinnitus Handicap Inventory (ΔTHI) score at 4, 8 weeks and 12 weeks after rTMS treatments compared with pre-treatment. However, there was no effect in the auditory only group. Also, there was no effect in sham group when THI scores were compared with that of the pre-treatment. These results are in line with the former studies that reported a better treatment effect by multiple site rTMS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex / Tinnitus Type of study: Clinical_trials Limits: Humans Language: En Journal: Brain Topogr Journal subject: CEREBRO Year: 2020 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex / Tinnitus Type of study: Clinical_trials Limits: Humans Language: En Journal: Brain Topogr Journal subject: CEREBRO Year: 2020 Document type: Article Country of publication: United States