ATM mediated-p53 signaling pathway forms a novel axis for senescence control.
Mitochondrion
; 55: 54-63, 2020 11.
Article
in En
| MEDLINE
| ID: mdl-32949791
ABSTRACT
Previously, we uncovered a novel mechanism in which senescence is controlled by mitochondrial functional recovery upon Ataxia-telangiectasia mutated (ATM) inhibition. However, it remains elusive how ATM controls signaling pathways to achieve restorative effect. In this study, we performed microarray and found that p53 pathway was differentially expressed upon ATM inhibition. We found that ATM inhibition yields senescence amelioration through p53-dependent manner. The restorative effect was also afforded by direct p53 inhibition. Furthermore, mitochondrial metabolic reprogramming via p53 inhibition was a prerequisite for senescence amelioration. Taken together, our data indicated that p53 pathway functions as potential target for ATM-mediated senescence amelioration.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Suppressor Protein p53
/
Fibroblasts
/
Ataxia Telangiectasia Mutated Proteins
Limits:
Humans
Language:
En
Journal:
Mitochondrion
Year:
2020
Document type:
Article
Affiliation country:
South Korea