Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours.

Mansur, Fernanda; Alarcon, Juan Marcos; Stackpole, Emily E; Wang, Ruijia; Richter, Joel D

Mansur, Fernanda; Alarcon, Juan Marcos; Stackpole, Emily E; Wang, Ruijia; Richter, Joel D.

Affiliation

Mansur F; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Alarcon JM; Department of Pathology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Stackpole EE; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Wang R; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Richter JD; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

RNA Biol ; 18(7): 962-971, 2021 07.

Article in En | MEDLINE | ID: mdl-32954964

Subject(s)

CA1 Region, Hippocampal/metabolism; Long-Term Potentiation/genetics; Polynucleotide Adenylyltransferase/genetics; RNA Processing, Post-Transcriptional; Transcription Factors/genetics; mRNA Cleavage and Polyadenylation Factors/genetics; 3' Untranslated Regions; Animals; Avoidance Learning/physiology; CA1 Region, Hippocampal/pathology; Gene Expression Regulation; Injections, Intraventricular; Isoenzymes/genetics; Isoenzymes/metabolism; Male; Maze Learning/physiology; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Obsessive Behavior/genetics; Obsessive Behavior/metabolism; Obsessive Behavior/physiopathology; Polynucleotide Adenylyltransferase/antagonists & inhibitors; Polynucleotide Adenylyltransferase/metabolism; Protein Biosynthesis; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Transcription Factors/antagonists & inhibitors; Transcription Factors/metabolism; Transcription, Genetic; mRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors; mRNA Cleavage and Polyadenylation Factors/metabolism

Key words

Noncanonical poly(A) polymerase; RNA-seq; alternative RNA processing; animal behaviour; synaptic plasticity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polynucleotide Adenylyltransferase / Transcription Factors / RNA Processing, Post-Transcriptional / Long-Term Potentiation / MRNA Cleavage and Polyadenylation Factors / CA1 Region, Hippocampal Limits: Animals Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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