Preclinical Development of Near-Infrared-Labeled CD38-Targeted Daratumumab for Optical Imaging of CD38 in Multiple Myeloma.

Cho, Nicholas; Ko, Sooah; Shokeen, Monica

Cho, Nicholas; Ko, Sooah; Shokeen, Monica.

Affiliation

Cho N; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ko S; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Shokeen M; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63110, USA.

Mol Imaging Biol ; 23(2): 186-195, 2021 04.

Article in En | MEDLINE | ID: mdl-32964391

Subject(s)

ADP-ribosyl Cyclase 1/metabolism; Antibodies, Monoclonal/pharmacokinetics; Indoles/pharmacokinetics; Membrane Glycoproteins/metabolism; Multiple Myeloma/diagnostic imaging; Optical Imaging/methods; Animals; Antibodies, Monoclonal/administration & dosage; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacokinetics; Cell Line, Tumor; Female; Humans; Immunotherapy/methods; Mice; Mice, SCID; Molecular Imaging/methods; Multiple Myeloma/drug therapy; Multiple Myeloma/metabolism; Multiple Myeloma/pathology; Tissue Distribution; Xenograft Model Antitumor Assays

Key words

Bone marrow; Cluster of differentiation 38 (CD38); Daratumumab (DARA); IRDye800CW; Multiple myeloma (MM); Near-infrared (NIR) fluorescence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / ADP-ribosyl Cyclase 1 / Optical Imaging / Indoles / Antibodies, Monoclonal / Multiple Myeloma Limits: Animals / Female / Humans Language: En Journal: Mol Imaging Biol Journal subject: BIOLOGIA MOLECULAR / DIAGNOSTICO POR IMAGEM Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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