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Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics.
Tucholski, Trisha; Cai, Wenxuan; Gregorich, Zachery R; Bayne, Elizabeth F; Mitchell, Stanford D; McIlwain, Sean J; de Lange, Willem J; Wrobbel, Max; Karp, Hannah; Hite, Zachary; Vikhorev, Petr G; Marston, Steven B; Lal, Sean; Li, Amy; Dos Remedios, Cristobal; Kohmoto, Takushi; Hermsen, Joshua; Ralphe, J Carter; Kamp, Timothy J; Moss, Richard L; Ge, Ying.
Affiliation
  • Tucholski T; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
  • Cai W; Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705.
  • Gregorich ZR; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.
  • Bayne EF; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.
  • Mitchell SD; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
  • McIlwain SJ; Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705.
  • de Lange WJ; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.
  • Wrobbel M; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53705.
  • Karp H; University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705.
  • Hite Z; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53705.
  • Vikhorev PG; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.
  • Marston SB; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.
  • Lal S; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705.
  • Li A; National Heart & Lung Institute, Imperial College London, London W12 0NN, United Kingdom.
  • Dos Remedios C; National Heart & Lung Institute, Imperial College London, London W12 0NN, United Kingdom.
  • Kohmoto T; School of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Camperdown, NSW 2006,Australia.
  • Hermsen J; School of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Camperdown, NSW 2006,Australia.
  • Ralphe JC; Department of Pharmacy & Biomedical Sciences, La Trobe University, Bundoora, VIC 3086, Australia.
  • Kamp TJ; School of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Camperdown, NSW 2006,Australia.
  • Moss RL; Department of Molecular Cardiology & Biophysics, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.
  • Ge Y; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.
Proc Natl Acad Sci U S A ; 117(40): 24691-24700, 2020 10 06.
Article in En | MEDLINE | ID: mdl-32968017
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcomeres / Cardiomyopathy, Hypertrophic / Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcomeres / Cardiomyopathy, Hypertrophic / Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article