Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider.

Garcia-Revilla, Juan; Deierborg, Tomas; Venero, Jose Luis; Boza-Serrano, Antonio

Garcia-Revilla, Juan; Deierborg, Tomas; Venero, Jose Luis; Boza-Serrano, Antonio.

Affiliation

Garcia-Revilla J; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Deierborg T; Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, BMC, Lund University, Lund, Sweden.
Venero JL; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Boza-Serrano A; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia and Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

Front Immunol ; 11: 2069, 2020.

Article in En | MEDLINE | ID: mdl-32973815

Subject(s)

Betacoronavirus/immunology; Coronavirus Infections/drug therapy; Galectin 3/antagonists & inhibitors; Galectin 3/blood; Molecular Targeted Therapy/methods; Pneumonia, Viral/drug therapy; Pulmonary Fibrosis/drug therapy; Severity of Illness Index; Angiotensin-Converting Enzyme 2; Animals; Betacoronavirus/chemistry; Biomarkers/blood; Blood Proteins; COVID-19; Coronavirus Infections/immunology; Coronavirus Infections/virology; Cytokines/antagonists & inhibitors; Cytokines/metabolism; Disease Progression; Galectins; Host-Pathogen Interactions/immunology; Humans; Inflammation/drug therapy; Inflammation/immunology; Pandemics; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; Prognosis; Pulmonary Fibrosis/immunology; SARS-CoV-2; Spike Glycoprotein, Coronavirus/metabolism

Key words

COVID-19; biomarker; cytokine storm; fibrosis; galectin-3

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Fibrosis / Severity of Illness Index / Coronavirus Infections / Galectin 3 / Molecular Targeted Therapy / Betacoronavirus Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Front Immunol Year: 2020 Document type: Article Affiliation country: Spain Country of publication: Switzerland

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