Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia.

Sobash, Philip T; Kolhe, Ravindra; Karim, Nagla Abdel; Guddati, Achuta K; Jillella, Anand; Kota, Vamsi

Sobash, Philip T; Kolhe, Ravindra; Karim, Nagla Abdel; Guddati, Achuta K; Jillella, Anand; Kota, Vamsi.

Affiliation

Sobash PT; Internal Medicine, White River Health System, Batesville, AR 72501, USA.
Kolhe R; Department of Pathology, Augusta University, Augusta, GA 30912, USA.
Karim NA; Medical Oncology, Augusta University, Augusta, GA 30912, USA.
Guddati AK; Medical Oncology, Augusta University, Augusta, GA 30912, USA.
Jillella A; Medical Oncology, Augusta University, Augusta, GA 30912, USA.
Kota V; Medical Oncology, Augusta University, Augusta, GA 30912, USA.

Future Oncol ; 16(36): 3085-3094, 2020 Dec.

Article in En | MEDLINE | ID: mdl-32976029

Subject(s)

Antineoplastic Agents/pharmacology; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism; Leukemia, Myeloid, Acute/immunology; Tumor Microenvironment/immunology; Antineoplastic Agents/therapeutic use; Cell Differentiation/drug effects; Cell Differentiation/immunology; Dendritic Cells/enzymology; Dendritic Cells/immunology; Disease Progression; Gene Expression Regulation, Leukemic/immunology; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics; Kynurenine/metabolism; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/mortality; Prognosis; Progression-Free Survival; Protein Processing, Post-Translational/immunology; Survival Rate; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism; Tryptophan/metabolism; Tumor Escape/drug effects; Tumor Escape/immunology; Tumor Microenvironment/drug effects; Up-Regulation/immunology

Key words

3-dioxygenase; T cells; acute myeloid leukemia; cancer; immunity; immunosuppression; indoleamine-2; kynurenines; metabolism; tolerance; tumor microenvironment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Indoleamine-Pyrrole 2,3,-Dioxygenase / Tumor Microenvironment / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Future Oncol Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom

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