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Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.
Brockunier, Linda; Stelmach, John; Guo, Jian; Spencer, Tracy; Rosauer, Keith; Bansal, Alka; Cai, Sheng-Jian; Chen, Nancy; Cummings, John; Huang, Li; Johnson, Timothy; Levesque, Sonia; Luo, Lin; Maloney, Kevin; Metzger, Joseph; Mortko, Christopher; Ortega, Karen; Pai, Lee-Yuh; Pereira, Antonio; Salituro, Gino; Shang, Jackie; Shepherd, Cherrie; Sherrie Xu, Shiyao; Yang, Qifeng; Cui, Jisong; Roy, Sophie; Parmee, Emma; Raghavan, Subharekha.
Affiliation
  • Brockunier L; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Stelmach J; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Guo J; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Spencer T; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Rosauer K; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Bansal A; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Cai SJ; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Chen N; In vivo pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Cummings J; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Huang L; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Johnson T; Investigative In-Vivo Safety Pharmacology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA.
  • Levesque S; In vivo pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Luo L; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Maloney K; Process Research & Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Metzger J; In vivo pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Mortko C; Discovery Pharmaceutical Science, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Ortega K; In vivo pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Pai LY; In vivo pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Pereira A; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Salituro G; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Shang J; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Shepherd C; In vivo pharmacology, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Sherrie Xu S; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Yang Q; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Cui J; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Roy S; Cardio-metabolic Disease, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Parmee E; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Raghavan S; Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: subha_raghavan@merck.com.
Bioorg Med Chem Lett ; 30(21): 127574, 2020 11 01.
Article in En | MEDLINE | ID: mdl-32980512
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Discovery / Soluble Guanylyl Cyclase / Hypertension / Antihypertensive Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Discovery / Soluble Guanylyl Cyclase / Hypertension / Antihypertensive Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States