Mutation of N-glycosylation Sites in Salmonid Alphavirus (SAV) Envelope Proteins Attenuate the Virus in Cell Culture.

Aksnes, Ida; Markussen, Turhan; Braaen, Stine; Rimstad, Espen

Aksnes, Ida; Markussen, Turhan; Braaen, Stine; Rimstad, Espen.

Affiliation

Aksnes I; Department of Paraclinical Sciences, Norwegian University of Life Sciences, 0454 Oslo, Norway.
Markussen T; Department of Paraclinical Sciences, Norwegian University of Life Sciences, 0454 Oslo, Norway.
Braaen S; Department of Paraclinical Sciences, Norwegian University of Life Sciences, 0454 Oslo, Norway.
Rimstad E; Department of Paraclinical Sciences, Norwegian University of Life Sciences, 0454 Oslo, Norway.

Viruses ; 12(10)2020 09 24.

Article in En | MEDLINE | ID: mdl-32987930

Subject(s)

Alphavirus/genetics; Alphavirus/pathogenicity; Salmon/virology; Trout/virology; Viral Envelope Proteins/genetics; Animals; Cell Line; Cytopathogenic Effect, Viral/genetics; Fish Diseases/virology; Glycosylation; Mutation/genetics; Vaccines, Attenuated; Viral Envelope Proteins/metabolism; Virulence/genetics

Key words

N-glycosylation; Pancreas disease; attenuation; k salmonid alphavirus; reverse genetics; virulence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salmon / Trout / Viral Envelope Proteins / Alphavirus Limits: Animals Language: En Journal: Viruses Year: 2020 Document type: Article Affiliation country: Norway

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