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RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice.
Karunakaran, Denuja; Turner, Adam W; Duchez, Anne-Claire; Soubeyrand, Sebastien; Rasheed, Adil; Smyth, David; Cook, David P; Nikpay, Majid; Kandiah, Joshua W; Pan, Calvin; Geoffrion, Michele; Lee, Richard; Boytard, Ludovic; Wyatt, Hailey; Nguyen, My-Anh; Lau, Paulina; Laakso, Markku; Ramkhelawon, Bhama; Alvarez, Marcus; Pietiläinen, Kirsi H; Pajukanta, Päivi; Vanderhyden, Barbara C; Liu, Peter; Berger, Scott B; Gough, Peter J; Bertin, John; Harper, Mary-Ellen; Lusis, Aldons J; McPherson, Ruth; Rayner, Katey J.
Affiliation
  • Karunakaran D; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. d.karunakaran@imb.uq.edu.au.
  • Turner AW; Cardiac Function Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. d.karunakaran@imb.uq.edu.au.
  • Duchez AC; Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia. d.karunakaran@imb.uq.edu.au.
  • Soubeyrand S; Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Rasheed A; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Smyth D; Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Cook DP; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Nikpay M; Cardiac Function Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Kandiah JW; Ottawa Hospital Research Institute, Centre for Cancer Therapeutics, Ottawa, Ontario, Canada.
  • Pan C; Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Geoffrion M; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Lee R; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Boytard L; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Wyatt H; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, CA, USA.
  • Nguyen MA; New York University Langone Medical Center, New York, NY, USA.
  • Lau P; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Laakso M; Cardiometabolic microRNA Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Ramkhelawon B; Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Alvarez M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Pietiläinen KH; New York University Langone Medical Center, New York, NY, USA.
  • Pajukanta P; Department of Human Genetics, and Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Vanderhyden BC; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism and Obesity Center, Endocrinology, Abdominal Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
  • Liu P; Department of Human Genetics, and Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Berger SB; Ottawa Hospital Research Institute, Centre for Cancer Therapeutics, Ottawa, Ontario, Canada.
  • Gough PJ; Cardiac Function Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Bertin J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Harper ME; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • Lusis AJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.
  • McPherson R; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Rayner KJ; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nat Metab ; 2(10): 1113-1125, 2020 10.
Article in En | MEDLINE | ID: mdl-32989316
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Silencing / Receptor-Interacting Protein Serine-Threonine Kinases / Obesity Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Nat Metab Year: 2020 Document type: Article Affiliation country: Canada Country of publication: Germany
Fulltext
Add to My VHL
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Silencing / Receptor-Interacting Protein Serine-Threonine Kinases / Obesity Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Journal: Nat Metab Year: 2020 Document type: Article Affiliation country: Canada Country of publication: Germany