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Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish.
Knuth, Megan M; Mahapatra, Debabrata; Jima, Dereje; Wan, Debin; Hammock, Bruce D; Law, Mac; Kullman, Seth W.
Affiliation
  • Knuth MM; Toxicology Program, Department of Biological Sciences, North Carolina State University, Campus Box 7633, Raleigh, NC, 27695-7633, USA. mmknuth@ncsu.edu.
  • Mahapatra D; Comparative Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA.
  • Jima D; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27606, USA.
  • Wan D; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27606, USA.
  • Hammock BD; Department of Entomology and Nematology and University of California Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, USA.
  • Law M; Department of Entomology and Nematology and University of California Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, USA.
  • Kullman SW; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27606, USA.
Sci Rep ; 10(1): 16032, 2020 09 29.
Article in En | MEDLINE | ID: mdl-32994480
ABSTRACT
Emerging evidence demonstrates the importance of sufficient vitamin D (1α, 25-dihydroxyvitamin D3) levels during early life stage development with deficiencies associated with long-term effects into adulthood. While vitamin D has traditionally been associated with mineral ion homeostasis, accumulating evidence suggests non-calcemic roles for vitamin D including metabolic homeostasis. In this study, we examined the hypothesis that vitamin D deficiency (VDD) during early life stage development precedes metabolic disruption. Three dietary cohorts of zebrafish were placed on engineered diets including a standard laboratory control diet, a vitamin D null diet, and a vitamin D enriched diet. Zebrafish grown on a vitamin D null diet between 2-12 months post fertilization (mpf) exhibited diminished somatic growth and enhanced central adiposity associated with accumulation and enlargement of visceral and subcutaneous adipose depots indicative of both adipocyte hypertrophy and hyperplasia. VDD zebrafish exhibited elevated hepatic triglycerides, attenuated plasma free fatty acids and attenuated lipoprotein lipase activity consistent with hallmarks of dyslipidemia. VDD induced dysregulation of gene networks associated with growth hormone and insulin signaling, including induction of suppressor of cytokine signaling. These findings indicate that early developmental VDD impacts metabolic health by disrupting the balance between somatic growth and adipose accumulation.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vitamin D / Vitamin D Deficiency / Adiposity Type of study: Etiology_studies Limits: Animals Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vitamin D / Vitamin D Deficiency / Adiposity Type of study: Etiology_studies Limits: Animals Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: United States