MKP-5 Relieves Lipotoxicity-Induced Islet ß-Cell Dysfunction and Apoptosis via Regulation of Autophagy.

Zhao, Tongjian; Ma, Jie; Li, Lulu; Teng, Wenjing; Tian, Yafei; Ma, Yongjun; Wang, Wei; Yan, Weiqun; Jiao, Ping

Zhao, Tongjian; Ma, Jie; Li, Lulu; Teng, Wenjing; Tian, Yafei; Ma, Yongjun; Wang, Wei; Yan, Weiqun; Jiao, Ping.

Affiliation

Zhao T; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Ma J; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Li L; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Teng W; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Tian Y; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Ma Y; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Wang W; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Yan W; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.
Jiao P; School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 130021, China.

Int J Mol Sci ; 21(19)2020 Sep 28.

Article in En | MEDLINE | ID: mdl-32998359

Subject(s)

Autophagy/genetics; Dual-Specificity Phosphatases/genetics; Islets of Langerhans/enzymology; Lipid Metabolism/genetics; Obesity/genetics; Adenine/analogs & derivatives; Adenine/pharmacology; Adenoviridae/genetics; Adenoviridae/metabolism; Animals; Apoptosis/drug effects; Apoptosis/genetics; Autophagy/drug effects; Diet, High-Fat/adverse effects; Dual-Specificity Phosphatases/metabolism; Gene Expression Regulation; Genetic Vectors/chemistry; Genetic Vectors/metabolism; Islets of Langerhans/cytology; Islets of Langerhans/drug effects; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; JNK Mitogen-Activated Protein Kinases/genetics; JNK Mitogen-Activated Protein Kinases/metabolism; Lipid Metabolism/drug effects; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; Obesity/enzymology; Obesity/etiology; Obesity/pathology; Palmitic Acid/antagonists & inhibitors; Palmitic Acid/toxicity; Primary Cell Culture; Protein Kinase Inhibitors/pharmacology; Signal Transduction; Transduction, Genetic; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

MKP-5; autophagy; islet cells; lipotoxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Islets of Langerhans / Lipid Metabolism / Dual-Specificity Phosphatases / Obesity Type of study: Etiology_studies Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Affiliation country: China Country of publication: Switzerland

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