A latent lineage potential in resident neural stem cells enables spinal cord repair.
Science
; 370(6512)2020 10 02.
Article
in En
| MEDLINE
| ID: mdl-33004487
ABSTRACT
Injuries to the central nervous system (CNS) are inefficiently repaired. Resident neural stem cells manifest a limited contribution to cell replacement. We have uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the injured mouse spinal cord. Integrating multimodal single-cell analysis, we found that neural stem cells are in a permissive chromatin state that enables the unfolding of a normally latent gene expression program for oligodendrogenesis after injury. Ectopic expression of the transcription factor OLIG2 unveiled abundant stem cell-derived oligodendrogenesis, which followed the natural progression of oligodendrocyte differentiation, contributed to axon remyelination, and stimulated functional recovery of axon conduction. Recruitment of resident stem cells may thus serve as an alternative to cell transplantation after CNS injury.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligodendroglia
/
Neurogenesis
/
Neural Stem Cells
/
Spinal Cord Regeneration
Limits:
Animals
Language:
En
Journal:
Science
Year:
2020
Document type:
Article
Affiliation country:
Sweden