A polylysine-polyhistidine fusion peptide for lysosome-targeted protein delivery.

Iwasaki, Takashi; Murakami, Nodoka; Kawano, Tsuyoshi

Iwasaki, Takashi; Murakami, Nodoka; Kawano, Tsuyoshi.

Affiliation

Iwasaki T; Department of Agriculture, Graduate School of Sustainability Science, Tottori University, Tottori, 680-8553, Japan. Electronic address: itaka@tottori-u.ac.jp.
Murakami N; Department of Agriculture, Graduate School of Sustainability Science, Tottori University, Tottori, 680-8553, Japan.
Kawano T; Department of Agriculture, Graduate School of Sustainability Science, Tottori University, Tottori, 680-8553, Japan.

Biochem Biophys Res Commun ; 533(4): 905-912, 2020 12 17.

Article in En | MEDLINE | ID: mdl-33008588

Subject(s)

Cell-Penetrating Peptides/administration & dosage; Cell-Penetrating Peptides/chemistry; Drug Delivery Systems; Enzyme Replacement Therapy/methods; Lysosomal Storage Diseases/drug therapy; Lysosomal Storage Diseases/enzymology; Lysosomes/drug effects; Lysosomes/metabolism; Amino Acid Sequence; Cells, Cultured; Fabry Disease/drug therapy; Fabry Disease/enzymology; Histidine/chemistry; Humans; Polylysine/chemistry; Protein Transport; Recombinant Fusion Proteins/administration & dosage; Recombinant Fusion Proteins/chemistry; alpha-Galactosidase/administration & dosage

Key words

Acidic protein; Cell-penetrating peptide; Drug delivery system; Lysosomal enzyme; Lysosomal storage disease; Lysosome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lysosomal Storage Diseases / Drug Delivery Systems / Enzyme Replacement Therapy / Cell-Penetrating Peptides / Lysosomes Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Country of publication: United States

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