Anti-cancer Immunotoxins, Challenges, and Approaches.
Curr Pharm Des
; 27(7): 932-941, 2021.
Article
in En
| MEDLINE
| ID: mdl-33023437
ABSTRACT
The development of recombinant immunotoxins (RITs) as a novel therapeutic strategy has made a revolution in the treatment of cancer. RITs result from the fusion of antibodies to toxin proteins for targeting and eliminating cancerous cells by inhibiting protein synthesis. Despite indisputable outcomes of RITs regarding inhibition of multiple cancer types, high immunogenicity has been known as the main obstacle in the clinical use of RITs. Various strategies have been proposed to overcome these limitations, including immunosuppressive therapy, humanization of the antibody fragment moiety, generation of immunotoxins originated from endogenous human cytotoxic enzymes, and modification of the toxin moiety to escape the immune system. This paper is devoted to review recent advances in the design of immunotoxins with lower immunogenicity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacterial Toxins
/
Immunotoxins
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Curr Pharm Des
Journal subject:
FARMACIA
Year:
2021
Document type:
Article
Affiliation country:
Iran