Cold-induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm.

Fischl, Harry; McManus, David; Oldenkamp, Roel; Schermelleh, Lothar; Mellor, Jane; Jagannath, Aarti; Furger, André

Fischl, Harry; McManus, David; Oldenkamp, Roel; Schermelleh, Lothar; Mellor, Jane; Jagannath, Aarti; Furger, André.

Affiliation

Fischl H; Department of Biochemistry, University of Oxford, Oxford, UK.
McManus D; Department of Biochemistry, University of Oxford, Oxford, UK.
Oldenkamp R; Department of Biochemistry, University of Oxford, Oxford, UK.
Schermelleh L; Department of Biochemistry, University of Oxford, Oxford, UK.
Mellor J; Department of Biochemistry, University of Oxford, Oxford, UK.
Jagannath A; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Furger A; Department of Biochemistry, University of Oxford, Oxford, UK.

EMBO J ; 39(22): e105604, 2020 11 16.

Article in En | MEDLINE | ID: mdl-33034091

Subject(s)

Cell Nucleus/metabolism; Chromatin/metabolism; Circadian Rhythm/physiology; Cold Temperature; RNA, Messenger/metabolism; Cell Line; Circadian Clocks/genetics; Circadian Clocks/physiology; Circadian Rhythm/genetics; Gene Knockout Techniques; Heterochromatin; Humans; Hypothermia/surgery; Transcriptional Activation; Transcriptome; Up-Regulation

Key words

REV-ERBα; chromatin compaction; circadian rhythm; cold stress; nuclear and cytoplasmic transcriptomes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Chromatin / Cell Nucleus / Circadian Rhythm / Cold Temperature Limits: Humans Language: En Journal: EMBO J Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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