Epidermal growth factor binding protein: identification of a different protein.
Biochemistry
; 26(8): 2082-5, 1987 Apr 21.
Article
in En
| MEDLINE
| ID: mdl-3304419
ABSTRACT
Partial amino acid sequence analysis of epidermal growth factor binding protein (EGF-BP), an arginine esteropeptidase that specifically associates with EGF to form a high molecular weight complex in male mouse submandibular glands, has revealed a single, distinct protein that is different from three previously reported forms of EGF-BP. This protein shows substantial sequence homology with these other putative forms of EGF-BP as well as with a large family of kallikreins expressed in the mouse submandibular gland. Purified EGF-BP contains three polypeptide chains as a result of two internal cleavages at residues 87-88 and 140-141. These modifications may represent processing events that are critical for determining the binding specificity of EGF-BP, since they occur within regions surrounding the substrate binding site.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endopeptidases
/
Submandibular Gland
/
Epidermal Growth Factor
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Biochemistry
Year:
1987
Document type:
Article