Familial aggregation of testicular cancer among early-onset cancer survivors. A prospective observational cohort data from Finland.
Cancer Epidemiol
; 69: 101807, 2020 12.
Article
in En
| MEDLINE
| ID: mdl-33045472
ABSTRACT
Testicular cancer (TC) is the most common form of cancer in men aged 15-35 years. Familial risk for TC is among highest of all cancers. MATERIAL AND METHODS:
A prospective observational cohort of 9111 relatives in 2,188 families of early-onset TC patients, called probands, diagnosed at age ≤40 years in Finland between 1970 and 2012. Standardized incidence ratios (SIR) were used as measures of familial aggregation for early-onset (≤40 years) TC. Follow-up ended at diagnosis of TC, death or 31 December 2014 whichever earliest.RESULTS:
Among first-degree relatives of early-onset TCs, in all 12 early-onset TC cases (0.24%) were diagnosed over the follow-up; the SIR for any first-degree relative was 4.59 (95% confidence interval (CI) 2.37-8.01) and for brothers the SIR was 6.51 (95% CI 3.12-11.96).DISCUSSION:
Familial aggregation of TC shows substantial risk for early-onset TC among first-degree relatives of early-onset TC patients in Finland. This is important to acknowledge to avoid diagnostic delay especially of TC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Testicular Neoplasms
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Cancer Epidemiol
Journal subject:
EPIDEMIOLOGIA
/
NEOPLASIAS
Year:
2020
Document type:
Article