Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.
Future Oncol
; 16(34): 2809-2819, 2020 Dec.
Article
in En
| MEDLINE
| ID: mdl-33052751
ABSTRACT
Aim:
To explore the prognostic significance of Syt-7 in hepatocellular carcinoma (HCC) and the potential mechanisms.Methods:
Immunohistochemistry was used to examine the expression of Syt-7. Overall survival and disease-free survival were compared between Syt-7 positive and negative groups. The effects of Syt-7 knockdown on BEL-7404 cells were further evaluated.Results:
Syt-7 expression was significantly higher in HCC tumorous tissues compared with paracancerous tissues. Syt-7 was closely associated with α-fetoprotein tumor size, vascular invasion, tumor node metastasis stage and tumor differentiation. Syt-7 was an independent risk factor for overall survival and disease-free survival. Additionally, Syt-7 knockdown inhibited proliferation and colony formation and induced cell cycle arrest in HCC cells.Conclusion:
Syt-7 overexpression forecasts unfavorable prognosis and promotes cell proliferation in HCC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Synaptotagmins
/
Liver Neoplasms
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Future Oncol
Year:
2020
Document type:
Article