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Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.
Inazumi, Tomoaki; Yamada, Kiyotaka; Shirata, Naritoshi; Sato, Hiroyasu; Taketomi, Yoshitaka; Morita, Kazunori; Hohjoh, Hirofumi; Tsuchiya, Soken; Oniki, Kentaro; Watanabe, Takehisa; Sasaki, Yutaka; Oike, Yuichi; Ogata, Yasuhiro; Saruwatari, Junji; Murakami, Makoto; Sugimoto, Yukihiko.
Affiliation
  • Inazumi T; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
  • Yamada K; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
  • Shirata N; Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
  • Sato H; Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan; AMED-CREST, J
  • Taketomi Y; Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan; AMED-CREST, J
  • Morita K; Department of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
  • Hohjoh H; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
  • Tsuchiya S; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
  • Oniki K; Department of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
  • Watanabe T; Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
  • Sasaki Y; Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
  • Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
  • Ogata Y; Japanese Red Cross Kumamoto Health Care Center, Kumamoto 861-8528, Japan.
  • Saruwatari J; Department of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
  • Murakami M; Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan; Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan; AMED-CREST, J
  • Sugimoto Y; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan; FORCE, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
Cell Rep ; 33(2): 108265, 2020 10 13.
Article in En | MEDLINE | ID: mdl-33053354
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Dinoprostone / Adiposity / Adipose Tissue, White / Receptors, Prostaglandin E, EP4 Subtype / Lipolysis Limits: Adult / Animals / Humans / Male Language: En Journal: Cell Rep Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Dinoprostone / Adiposity / Adipose Tissue, White / Receptors, Prostaglandin E, EP4 Subtype / Lipolysis Limits: Adult / Animals / Humans / Male Language: En Journal: Cell Rep Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United States