Consumption of multiple micronutrients or small-quantity lipid-based nutrient supplements containing iodine at the recommended dose during pregnancy, compared with iron and folic acid, does not affect women's urinary iodine concentration in rural Malawi: a secondary outcome analysis of the iLiNS DYAD trial.
Public Health Nutr
; 24(10): 3049-3057, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-33054890
ABSTRACT
OBJECTIVES:
Inadequate iodine intake during pregnancy increases the risk of neonatal morbidity and mortality. We aimed to evaluate whether prenatal supplements containing iodine affect urinary iodine concentrations (UIC) of pregnant women in Malawi.DESIGN:
A randomised controlled trial. Pregnant women (n 1391) were assigned to consume 60 mg/d Fe and 400 µg/d folic acid (IFA) or 18 vitamins and minerals including 250 µg/d iodine (MMN) or 20 g/d small-quantity lipid-based nutrient supplements (SQ-LNS) with similar nutrient contents as MMN group, plus macronutrients (LNS) until childbirth. In a sub-study (n 317), we evaluated group geometric mean urinary iodine concentration (UIC) (µg/L) at 36 weeks of gestation controlling for baseline UIC and compared median (baseline) and geometric mean (36 weeks) UIC with WHO cut-offs UIC < 150, 150-249, 250-499 and ≥500 reflecting insufficient, adequate, above requirements and excessive iodine intakes, respectively.SETTING:
Mangochi District, Malawi.PARTICIPANTS:
Women ≤20 weeks pregnant.RESULTS:
Groups had comparable background characteristics. At baseline, overall median (Q1, Q3) UIC (319 (167, 559)) suggested iodine intakes above requirements. At 36 weeks, the geometric mean (95 % CI) UIC of the IFA (197 (171, 226)), MMN (212 (185, 243)) and LNS (220 (192, 253)) groups did not differ (P = 0·53) and reflected adequate intakes.CONCLUSIONS:
In this setting, provision of supplements containing iodine at the recommended dose to pregnant women with relatively high iodine intakes at baseline, presumably from iodised salt, has no impact on the women's UIC. Regular monitoring of the iodine status of pregnant women in such settings is advisable. Clinicaltrials.gov identifier NCT01239693.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Folic Acid
/
Iodine
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Country/Region as subject:
Africa
Language:
En
Journal:
Public Health Nutr
Journal subject:
CIENCIAS DA NUTRICAO
/
SAUDE PUBLICA
Year:
2021
Document type:
Article
Affiliation country:
Ghana