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Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.
Rimel, Jenna K; Poss, Zachary C; Erickson, Benjamin; Maas, Zachary L; Ebmeier, Christopher C; Johnson, Jared L; Decker, Tim-Michael; Yaron, Tomer M; Bradley, Michael J; Hamman, Kristin B; Hu, Shanhu; Malojcic, Goran; Marineau, Jason J; White, Peter W; Brault, Martine; Tao, Limei; DeRoy, Patrick; Clavette, Christian; Nayak, Shraddha; Damon, Leah J; Kaltheuner, Ines H; Bunch, Heeyoun; Cantley, Lewis C; Geyer, Matthias; Iwasa, Janet; Dowell, Robin D; Bentley, David L; Old, William M; Taatjes, Dylan J.
Affiliation
  • Rimel JK; Department of Biochemistry, University of Colorado, Boulder, Colorado 80303, USA.
  • Poss ZC; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.
  • Erickson B; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
  • Maas ZL; UC-Denver RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
  • Ebmeier CC; Department of Biochemistry, University of Colorado, Boulder, Colorado 80303, USA.
  • Johnson JL; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.
  • Decker TM; BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
  • Yaron TM; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.
  • Bradley MJ; Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
  • Hamman KB; Department of Biochemistry, University of Colorado, Boulder, Colorado 80303, USA.
  • Hu S; Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10065, USA.
  • Malojcic G; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York 10065, USA.
  • Marineau JJ; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York 10065, USA.
  • White PW; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York 10065, USA.
  • Brault M; Syros Pharmaceuticals, Massachusetts 02140 USA.
  • Tao L; Syros Pharmaceuticals, Massachusetts 02140 USA.
  • DeRoy P; Syros Pharmaceuticals, Massachusetts 02140 USA.
  • Clavette C; Syros Pharmaceuticals, Massachusetts 02140 USA.
  • Nayak S; Syros Pharmaceuticals, Massachusetts 02140 USA.
  • Damon LJ; Paraza Pharma, Inc., Montreal, Quebec H4S 1Z9, Canada.
  • Kaltheuner IH; Paraza Pharma, Inc., Montreal, Quebec H4S 1Z9, Canada.
  • Bunch H; Paraza Pharma, Inc., Montreal, Quebec H4S 1Z9, Canada.
  • Cantley LC; Paraza Pharma, Inc., Montreal, Quebec H4S 1Z9, Canada.
  • Geyer M; Paraza Pharma, Inc., Montreal, Quebec H4S 1Z9, Canada.
  • Iwasa J; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
  • Dowell RD; Department of Biochemistry, University of Colorado, Boulder, Colorado 80303, USA.
  • Bentley DL; BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, USA.
  • Old WM; Institute of Structural Biology, University of Bonn, Bonn 53127, Germany.
  • Taatjes DJ; School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Genes Dev ; 34(21-22): 1452-1473, 2020 11 01.
Article in En | MEDLINE | ID: mdl-33060135
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Cyclin-Dependent Kinases / Transcription Factor TFIIH / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Cyclin-Dependent Kinases / Transcription Factor TFIIH / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States