HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation.
J Infect Dis
; 223(11): 1934-1942, 2021 06 04.
Article
in En
| MEDLINE
| ID: mdl-33075121
ABSTRACT
Individuals infected with human immunodeficiency virus (HIV) 1 have increased inflammation, which has been associated with age-associated diseases. Plasma markers, cell-associated virus levels, and ability to stimulate RNA transcription in latently infected cell lines was examined in younger and older HIV-1-infected individuals with suppressed virus. Cell-associated RNA, but not intact provirus level, had positive correlation with plasma D-dimer levels. Compared with the younger group, the older group had higher D-dimer levels and a trend toward more cell-associated RNA but similar levels of intact proviruses. Even though all measured inflammatory markers were relatively higher in the older group, this greater inflammation did not induce more HIV-1 transcription in latently infected cell lines. Inflammation and HIV-1 RNA expression increase with age despite similar levels of intact infectious HIV DNA. While plasma inflammation is correlated with HIV-1 RNA expression in peripheral blood mononuclear cells, it does not induce HIV-1 transcription in latently infected cell lines.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV-1
/
Proviruses
/
Inflammation
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Infect Dis
Year:
2021
Document type:
Article
Affiliation country:
United States