Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid.
Prostaglandins Other Lipid Mediat
; 152: 106502, 2021 02.
Article
in En
| MEDLINE
| ID: mdl-33075476
ABSTRACT
12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is a 17-carbon hydroxy fatty acid that is biosynthesized either by enzymatic pathways, like thromboxane synthase (TXAS) and cytochrome P450 or a non-enzymatic pathway. TXAS catalyzes the isomerization reaction from PGH2 to 12-HHT, malondialdehyde, and TXA2 at a ratio of 111. Furthermore, 12-HHT has been considered as a mere byproduct of TXA2 biosynthesis, and its biological function has long been uncertain. BLT2 was initially identified as a low-affinity leukotriene B4 (LTB4) receptor, which is also activated by various hydroxy-eicosatetraenoic acids (HETEs), suggesting that BLT2 may be activated by other endogenous ligands apart from LTB4 and HETEs. By unbiased ligand screening using crude lipids from rat organs, 12-HHT has been identified as an endogenous agonist for BLT2. The 12-HHT-BLT2 axis induces mast cell migration and contributes to allergic inflammation. BLT2 is also expressed in epithelial cells of the small intestine and skin in mice and contributes to in vivo epithelial barrier functions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Leukotriene B4
/
Leukotriene B4
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Fatty Acids, Unsaturated
Limits:
Animals
Language:
En
Journal:
Prostaglandins Other Lipid Mediat
Journal subject:
ENDOCRINOLOGIA
Year:
2021
Document type:
Article